Key challenges in tackling Worldwide Dementia
through the work of our global teams:
Research plays an important role in reducing the societal and health burden of disease, but dementia research has been historically under-funded. Far less is spent on public sector dementia research than on other major diseases globally, including by prevalent cases and as a percentage of different countries’ health and social care expenditure.
To see what WDC is doing to address the financial issues of dementia, please visit
Integrated Drug Development
The past decade has seen very little in the way of successful progress in dementia drug development and the disease has suffered from a lack of funding in innovation, research and development. Part of the problem is the high failure rate of candidate drugs, predominantly in the early stages of development, which is symptomatic of the gaps in knowledge around the disease’s biology. There is also a need for better understanding of the regulatory challenges the disease presents. All of these issues lead to slow and inefﬁcient translation of research into successful clinical results that can pave the way to finding a cure for dementia.
To see what WDC is doing to address issues with dementia drug development, please visit
Research, Open Science and Big Data
There has been too little success to date in finding a cure or a disease-modifying treatment for dementia: only three new drugs have entered the market in the past fifteen years. Furthermore, there still isn’t a shared understanding of dementia pathology, which critically impedes efforts to find effective treatments and hinders approaches to risk reduction, diagnosis and care.
The level of complexity of dementia is so high that no single country has the expertise or resources to address all these issues alone. There needs to be more global collaboration in research and more extensive data sharing if progress in developing effective drugs for dementia is going to be made.
To find out what WDC is doing to address the research, open science and big data related issues of dementia, please visit
Forty-four million people - and rising - currently live with dementia and the quality of care they receive varies greatly both within and between countries. Improving dementia care and support remains a top priority for care providers and those affected by the disease, especially while no cure or disease-modifying therapy is available.
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Not enough is currently being done by global governments to actively encourage people to reduce their risk of dementia, including by living more active lives. There needs to be a substantial investment in research and awareness programmes to better understand the risk factors that contribute to the disease’s development and to alert the public to the actions they can take to reduce their risk of dementia.
To see what WDC is doing to reduce the risk of dementia, please visit